Scientists from the UK’s New and Emerging Respiratory Virus Threats Advisory Group (NERVTAG) say they are now “highly confident” the new variant of coronavirus is more infectious than others, with a “hint” that it could be more transmissible in children.
According to NERVTAG, the new variant — which is believed to have originated in southeast England — could be around 71% more transmissible than other variants.
“As of last Friday, we felt we had moderate confidence because the data was coming in, but some of the analysis had been done very quickly,” Peter Horby, professor of emerging infectious diseases at the University Oxford and chair of NERVTAG, said during a virtual news briefing on Monday.
“We now have high confidence that this variant does have a transmission advantage over other virus variants that are currently in the UK,” he added.
Speaking alongside Horby, Professor Neil Ferguson from Imperial College London noted that there is a “hint” that this variant “has a higher propensity to infect children,” compared with earlier strains. But he cautioned that “we haven’t established any sort of causality on that, but we can see that in the data,” he added.
Another NERVTAG member, Wendy Barclay, head of the Department of Infectious Disease at Imperial College London, said earlier strains of the virus may have had a “harder time” getting into human cells using a receptor called ACE2. Adults, who have a lot of this receptor in their noses and throats, are “easy targets” compared to children. But under this hypothesis, a virus that can more readily use this receptor to enter cells may make children just as susceptible to the virus as adults, she said.
According to the US Centers for Disease Control and Prevention, some research suggests the UK strain may “bind more tightly” to the ACE2 receptor, but “it is unknown whether that tighter binding, if true, translates into any significant epidemiological or clinical differences.”
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